Abstract: Based on an analysis of the regional and urban spatial requirements for the layout of Shenzhen railway, the deficiencies of the existing railway lines are discussed, three planning strategies are proposed, including promoting the hub position of Shenzhen in high-speed railway network, building an intercity railway network with Shenzhen as the core, and bringing railway facilities into full play to support the urban space. On this basis, the construction of regional traffic organization model with "high-speed railway+intercity railway" as the backbone is put forward, aiming to support the development of Guangdong-Hong Kong-Macao Greater Bay Area towards the world-class bay area and that of Shenzhen towards a world-class city.