Abstract: To verify the feasibility analysis of straddle monorail vehicle bogie frame fatigue life by using computer simulation analysis, a finite element model is established, and the stress results are calculated by applying the unit load. The load time history obtained by the simulation analysis and the load time history obtained by the test are used as load excitation respectively. Then, according to the S-N curve and the Miner Rule, the bogie frame fatigue life is predicted combined with the fatigue analysis software Ncode. Based on the simulated load time history, the fatigue life is predicted as 56.1 years, while based on the experimental load time course, the fatigue life is 62 years. The results of the two fatigue life analyses are very similar, indicating that it is feasible to predict the fatigue life based on simulation.