Abstract: In order to predict accurately the structure noise on the elevated rail transit trough beam induced by passing trains, analyze the influence of plate thickness on the sonic radiation, combined with the finite element transient boundary element method, a vibration analysis model of vehicle bridge coupling system and a finite element/boundary element model of the trough girder structural acoustic radiation are established by adopting the collaborative joint simulation analysis method of multi-body dynamics software SIMPACK and finite element software ANSYS. Through analyzing the vibration and acoustic radiation characteristics of beam bridge under train load slot, the influences of the plate thickness on the bottom beam structural noise are discussed. The result shows that when the subway train passing through the trough girder bridge at the speed of 80 km/h, the bridge deck vibration and the structural noise are mainly concentrated on the near bottom; with the increase of plate thickness, the trough bridge structure radiation noise is reduced significantly in the near sound field, which has some influence on the far sound field to a certain extent. This research provides a theoretical basis for the noise reduction of rail transit trough beam structural vibration.