Abstract: Based on years of operating experiences and the extensive collection of actual“Pain Points”in subway vehicle operation and maintenance under its jurisdiction，Guangzhou Metro builds the intelligent operation and maintenance system by optimizing the existing maintenance process，increasing the on-board and track side monitoring and testing equipment，adopting the advanced big data，cloud computing and other technical means. This system can simulate， evaluate and optimize the whole vehicle operation process through improving the intelligent decision-making system，work coordination and information sharing. Moreover，based on the whole vehicle life cycle data，the system can provide the management and prediction data of the faults and service life management during the whole life cycle of the vehicle. Finally，it provides technical support for the gradual transformation of vehicle maintenance from scheduled maintenance to condition-based maintenance.