Abstract: With an analysis of the single-axle bogie structure and air suspension, the dynamic topological structure of monorail vehicle system is established, and the dynamic software SIMPACK is used to build a dynamic simulation model. Then, with the sensitivity analysis of ModeFRONTIER software, the parameters of the single-axle bogie air suspension are screened. Thus, the parameters that have significant influence on the oriented torque and the corning force of running wheel are obtained, they are the longitudinal stiffness, longitudinal damping and vertical damping of the air suspension respectively. An improved genetic algorithm is used to implement multiple-target optimization for the above three parameters. The oriented toque after improvement is reduced by 4.76% and the corning force of running wheel by 7.57%, resulting in better vehicle curve passing performance.