Abstract: Under the requirements of metro seismic design code, the T-type interchange station of Longhu North Station on Zhengzhou metro Line 6 is taken as the study case, the differences between time-history analysis method and response displacement method in seismic design calculation of the T-type station structure are compared and analyzed. Results show that the stress force law of the main parts in both open sections and standard sections of T-type interchange station structure acts generally the same, however the calculation results of the two analyzing methods in the sections display a simultaneous existence of disparity and similarity. The degree of difference depends on the specific location. In order to improve the reliability of the seismic design of T-type station structure, both methods should be used to calculate the station structure in accordance with the code requirements. The response displacement method provides certain level of reference value for the seismic design of T-type metro interchange station, while in practical design, depending on specific parts of the section, the time-history analysis method may serve as the main and the response displacement method the supplement.