Abstract: In urban rail transit field, the connection of vehicle and signaling system in large-capacity metro projects generally adopts interface mode, the hidden dangers and problems of which frequently impact on train operations, it has not been solved effectively for a long time. The connection of medium-capacity straddle monorail vehicle and signaling system adopts the fusion mode, which not only solves the interface problem, but also decreases the impact on operation effectively. In this paper, the fusion design and implementation of straddle monorail vehicle and signaling system is introduced.