Abstract: The metro vehicle depot is mainly responsible for the parking,maintenance and preparation of vehicles,among which maintenance includes multi-professional cross operations such as vehicle,catenary,signal equipment. It is of great significance to improve the working efficiency of vehicle base,to strengthen the safety of driving and personnel by using automatic means to manage the maintenance operation of vehicle depot safely and efficiently. Main safety risks of the maintenance operation in the metro automation depot are analyzed,and the composition,functionality,purpose,entry and more aspects of the metro integrated automation depot maintenance operation safety management and control system are introduced. The safety control mechanism of the maintenance operation procedure of this system is expounded.