Abstract: Based on the characteristics of integrated supervision and control system data flow, communication encryption scheme of the integrated supervision and control system is expounded from perspectives including encryption algorithm, key coordination mechanism and communication decryption principles and procedure. The application performance of the communication encryption scheme is analyzed from two aspects, order transmission time and system performance verification. Through laboratory test, third party test and Zhengzhou Line 14 integrated monitoring system engineering field test, the performance of integrated supervision and control system after implementing the scheme is proved to fully meet demands.