Abstract: On the basis of discussing the general principle and research scope of entrances and exits layout planning of urban rail transit station, the GIS database of station entrances and exits layout planning is established on the GIS platform, and the selection principle of alternative station entrances and exits and the generation method for the alternative schemes are put forward. With the optimization objective of minimizing the total social cost, the genetic algorithm principle is used to work out the optimal layout scheme of station entrances and exits, and the feasibility of the layout planning method is verified with case study.