Abstract: Based on the matching development process of urban rail transit ISCS and operation mode, the relationship between ISCS and operation scenarios under the condition of fully automatic operation is introduced, and the setting principle of ISCS and dispatcher of OCC under the condition of fully automatic operation is put forward. The interface scheme of ISCS and various electromechanical systems including signaling system is given. The train ground wireless communication of vehicle monitoring information and the security strategy of system are presented. The adaptability of the cloud platform and ISCS under the condition of fully automatic operation is expounded.