Abstract: With the development of urban construction, in the large passenger flow corridor of urban area, due to the limited passage resources and the shortage of land resources, it is inevitable for expressway and city line to share passage. At present, the existing engineering cases in China are all of sharing between one expressway and one urban rail transit, while there′s no precedent cases of expressway and two city lines sharing passage. Taking the project of Wenzhou S2, S3 City Lines and Wenrui Avenue Expressway as background, comprehensively considering factors including environmental impact, rational construction sequence and land intensive use, in line with the premises of urban road network layout, traffic and economic coordinated development, research on integrated layout scheme is carried out. The proposed overall layout scheme can not only meet the traffic function requirements of expressway itself, but also coordinate the overall construction of multiple traffic modes including city lines and expressway.