Abstract: Atrium-style metro station opens up the enclosed underground space. However, it will lead to discontinuity in horizontal structure where the atrium is located. Targeting special form metro station in Shanghai soft soil area with both standard 2-storey 3-span box structure and large opening atrium structure, by establishing a soil\|structure full 3D finite element model, seismic response of station structure under three ways of earthquake excitation including horizontal input from lateral direction, horizontal input from lateral and longitudinal direction, and horizontal input from both direction and vertical input is studied. Structure displacement and internal force response analysis indicate that there is spatial effect in seismic response of atrium-style metro station structure, and horizontal input from both longitudinal direction and vertical direction earthquake motion components have relatively strong impact on seismic response.