Abstract: Transportation hub is one of the key urban infrastructures. Targeting the structure layout feature of 'dumbbell' of Lanzhou Zhongchuan Airport Terminal 3 + GTC (global transportation center) + national railway/metro, a 3D structural finite element model that includes national railway station and interval tunnel, metro station and interval tunnel, T3 building, GTC is established. Site artificial seismic wave is input to study the structure dynamic response time history under 7-degree earthquake fortification design in the model. Evaluation is carried out on structure aseismic performance, connection between national railway/metro interval structure and station main-body structure and aseismic design. Design optimization, performance improvement and construction convenience are achieved, providing suggestion and theoretical support for Lanzhou Zhongchuan Airport T3, GTC, national railway/metro combination structure design.