Abstract: To investigate the weak link and most unfavored position of shield method construction station and the system under seismic motion, a three-dimensional refined finite element numerical model of station-passage-entry/exit Building system is established.The seismic dynamic response law of the system is studied. By inputting the transverse and longitudinal fortification seismic motion time-history and emphatically considering the seismic dynamic response of passage-station section, the stress, damage and deformation patterns of the structural system are investigated. Results show that the most unfavored locations of the station-passage-entry/exit Building system are the connecting part between the passage and the station as well as that between the passage and the entry/exit building. Seismic motion input is more harmful to the structural system in longitudinal direction than in transverse direction. The deformation pattern of the station-passage-entry/exit Building system is mainly determined by the non-uniform deformation between the entry/exit building and the station. The station exhibits squeeze deformation at the openings under transverse seismic action and torsional deformation under longitudinal seismic action.