Abstract: Large-scale shaking table single direction seismic test of cross interchange station in soft soil is designed and conducted. From dynamic balance equation, a similar design method based on synthetic model soil is proposed. The model station structure adopts granular concrete and galvanized steel wire, taking soil-structure relative stiffness as control index. Based on shaking table test, the structure seismic response characteristics of two-storey and three-storey cross-type interchange station in soft soil is studied, and parallel tests of single station are carried out for reference. Test results show that with ground motion enhances, the soil shear modulus attenuation grade increases. Due to the differential restrained effects of the interchange station structure, near-field soil acceleration experience spatially different phenomenon, and the amplitude is overall smaller than in the free-field. The bending strains of 3rd level underground middle column at interchange station cross joint is significantly higher than that of the first and second level underground, raising concern for future seismic design.