Abstract: Taking Beijing-Shanghai Highspeed Railway and Zaozhuang City as the research objects, the impact of high-speed railway on urban space development and urban economy transformation is decomposed. Research shows that, Zaozhuang City has successfully obtained phased result of urban transformation development with the help of Beijing-Shanghai High-speed Railway corridor. The reason for its success lies in maximizing the positive effect of the Beijing-Shanghai High-speed Railway corridor through systematic planning means, and scientifically guided the flow of talents, technology, information, capital and other production factors to gather in Zaozhuang. From the experience of Zaozhuang, it can be concluded that the high-speed railway corridor plays a positive role in promoting balanced development of cities and regions.