Abstract: Relying on an interval tunnel project of Guangzhou Metro under-passing dense urban building group, MIDAS GTS NX software is adopted to simulate the construction process, the ground and surface building subsidence law when the shield passes through composite strata such as water-rich gravel sand, silty clay and completely-slightly weathered granite is studied. The effectiveness of the inter-line grouting reinforcement and the raft structure reinforcement schemes are comparatively analyzed. Research results show that, compared with the raft structure reinforcement scheme, the inter-line grouting reinforcement scheme can significantly control the deformation and instability of the building, the pile foundation supporting layer, and the seepage loss of fissure water. The proposed empirical formula method is suitable for the stratum subsidence deformation prediction under inter-line grouting reinforcement working condition.