Abstract: To improve the functionality of urban rail transit station design, the use of CSFT (concrete filled steel tube) column with increased column spacing is a common approach. The seismic vulnerability of a large span CSFT column station needs to be studied, and the stress characteristics and seismic performance of CSFT columns need to be compared with conventional reinforced concrete columns. Taking an urban rail transit station with CFST column in southern China as prototype, a 3D calculation model is established using Midas GTS NX software, and its seismic vulnerability is studied. The static pushover analysis method is used to determine the station structure damage indexes. 10 natural seismic waves are selected, and IDA (incremental dynamic analysis) is performed to obtain the relative displacement angles of the station under various seismic actions. The results of the IDA are fitted to a logarithmic normal distribution to obtain the seismic vulnerability curve of the station. Results show that when the peak seismic acceleration is 0.8 g (g as the gravitational acceleration), the probability of slight damage to the CFST station structure is 83.46%, the probability of severe damage is 15.21%, and the probability of collapse is 4.26%. Compared with a common concrete frame structure station, CFST column station demonstrates better seismic performance.