Abstract: Objective: To assist metro department in formulating vehicle wheelset re-profiling strategy, a better wheel re-profiling mileage node is selected and the template schemes for each re-profiling operation are formulated, with the goal of prolonging wheel service life while ensuring economic efficiency.Method: Starting from the three indexes: flange wear area, diameter loss of re-profiled wheel and wheel diameter, an economic re-profiling model studying the wear law of the entire train is established. Based on the model, a metro case is studied. After obtaining the wear change law of the above three indexes for metro train wheels, the data is input into the established model for iterative calculation. Based on different indicators at different re-profiling mileage nodes in calculation results such as wheel lifespan, mileage per unit cost, and available mileage after the final re-profiling operation, the principles for selecting the optimal re-profiling mileage nodes are formulated. Finally, based on the calculation results and the proposed principles, the optimal economic re-profiling mileage nodes and template selection schemes are given. Result & Conclusion: Research results show that if the new wheels of a metro train are initially re-profiled using the template with flange thickness of 30 mm, and the template with flange thickness of 28 mm for the subsequent re-profiling, then compared to the metro department past practice of re-profiling wheels at around 312 000 km of train operation mileage, the model calculation recommends an optimal re-profiling mileage node of 217 000 km, which can extend the wheel lifespan total mileage by a maximum of 117 000 km and the wheel lifespan itself by 8.3% while ensuring the economic efficiency of re-profiling.