Abstract: Objective With With the increasing demands for multi-system coordinated rail transit development in China under the "four-network integration"（mainline railways, intercity railways, suburban railways, and urban rail transit） framework, train integration control technology based on TSN（time-sensitive networking） has become a key enabling the interoperability between urban rail, intercity, and regional railway systems. Therefore, it is necessary to study a collaborative optimization method for train wheel-rail adhesion control and safety resilience under the "four-network integration" scenario. Method In response to the high adhesion control requirements for multi-train-type coordinated operation, such as metro and intercity trains, within the "fournetwork integration", and combined with the characteristics of the integrated control architecture, a comprehensive wheel-rail adhesion optimization strategy based on creep-acceleration dual-mode control is proposed. This strategy dynamically evaluates the train reference speed, integrates creep rate feedback and acceleration threshold judgement, achieves accurate identification of wheel idling/slipping states under various operating scenarios and coordinated torque regulation, thereby enhancing traction system compatibility and adaptability across different rail systems. Result ＆ Conclusion Validated through full-vehicle type testing of metro trains and dedicated testing under the "four-network integration" scenarios, the proposed optimization strategy effectively improves train wheel-rail adhesion utilization rate in complex rail network environments. It provides technical support for optimizing train wheel-rail safety resilience and collaborative multi-network operation/maintenance under the "four-network integration" framework.