Abstract: The national standards of internet safety classified protection 2.0 and urban rail transit ISCS (integrated supervisory control system) have been implemented, and it has become a trend to construct the ISCS information security in accordance with the classified protection level 3. In line with the requirements of national classified protection standards, current situation and existing problems of ISCS information security are analyzed. Design scheme of ISCS information security centering ‘one center, triple protection’ is put forward, and implementation suggestions in terms of ISCS network security architecture and information security function settings are provided.